When it comes to making a grip, your thumb is actually the weakest part of the equation. For example, if someone standing directly in front of you grabs your wrist in a hostile fashion, the easiest way to break that person's grip is to work against the thumb (because it is weak). This type of hostile grab can usually be eliminated just by making a quick motion with your wrist, as if looking at your watch. When it comes to the kimura grip, an opposing thumb is generally disfavored (because it is the weak link in the grip), as opposed to getting all of your fingers aligned in the same direction where your grip is very strong. This grip also allows you to torque your opponent's wrist in toward you (like throttling a motorcycle), which makes the grip even more difficult to escape. As others have said, they are little nuances that make a big difference.