I found this.
http://www.whiteman.af.mil/news/story.asp?id=123063315
"One of the "hidden" ingredients in this blend is an herb called rutaecarpine. This ingredient is an alkaloid isolated from the traditional Chinese medicine, evodia rutaecarpa.
Studies have shown that this ingredient, rutaecarpine, can affect the P-450 enzyme system of the liver. Bottom line, it can cause serious damage to your liver and lead to devastating consequences.
We found out about it's affect on the liver when we found abnormally elevated liver enzymes on a few patients during routine evaluation and laboratory testing, which there was no apparent explanation or exam findings to correlate the lab results.
After more in depth questioning, we found the patients had been using the supplement. After one month of remaining off NO-Xplode™, the livers had completely returned to normal. "