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Main Card (ESPN+)
Al Iaquinta (14-4-1) vs. Donald Cerrone (35-11) (Lightweight)
Derek Brunson (18-7) vs. Elias Theodorou (16-2) (Middleweight)
Cub Swanson (25-10) vs. Shane Burgos (11-1) (Featherweight)
Brad Katona (8-0) vs. Merab Dvalishvili (8-4) (Bantamweight)
Walt Harris (11-7) vs. Sergey Spivak (9-0) (Heavyweight)
Marc-Andre Barriault (11-1) vs. Andrew Sanchez (10-4) (Middleweight)
Preliminary Card (ESPN+)
Macy Chiasson (4-0) vs. Sarah Moras (5-4) (Women's Bantamweight)
Aiemann Zahabi (7-1) vs. Vince Morales (8-3) (Bantamweight)
Nordine Taleb (14-6) vs. Kyle Prepolec (12-5) (Welterweight)
Kyle Nelson (12-2) vs. Matt Sayles (7-2) (Featherweight)
Arjan Bhullar (8-1) vs. Juan Adams (5-0) (Heavyweight)
Mitch Gagnon (12-4) vs. Cole Smith (6-0) (Bantamweight)
Other
- A heavyweight bout between Walt Harris and Alexey Oleynik was originally scheduled to take place at this event. However on April 3, it was announced that Oleinik would be replacing Alexander Volkov against Alistair Overeem in the main event of UFC on ESPN+ 7. He was replaced by Sergey Spivak on April 10.
- Leah Letson was expected to face Sarah Moras at the event. However, Letson was removed from the fight in early April for an unspecified medical issue and was replaced by Macy Chiasson on April 3.
- Brian Kelleher was expected to face Mitch Gagnon at the event. However, Kelleher pulled out of the fight on April 10 citing injury and was replaced by promotional newcomer Cole Smith on April 11.
- A welterweight bout between Siyar Bahadurzada and Nordine Taleb was scheduled to take place at the event. However on April 24, it was reported that Bahadurzada pulled out of the bout citing injury and was replaced by newcomer Kyle Prepolec on April 28.