You think you can hit a charging Grizzly in the head at 25 feet with a Desert Eagle? I’ve been an outdoorsman my entire life, logged 1000’s of hours hunting from Montana to New Mexico, not to mention back country camping and fishing. With all this experience I am confident that you’d be lucky to even hit a charging Grizzly, let alone stop it mid charge with a head shot. With a Desert Eagle I’d highly doubt you’d even get the second shot off before the Bear runs right through you.
A charging Grizzly will cover 25 feet in about three strides, maybe maybe giving you at most 1 second to land a ridicules head shot. And forget about the follow up, the recoil alone takes that option away.